PDBe 4jao

X-ray diffraction
2.05Å resolution

Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-pyrone synthesis polyketide synthase-like Pks11 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 353 amino acids
Theoretical weight: 37.68 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Mycobacterium smegmatis
UniProt:
  • Canonical: P9WPF3 (Residues: 1-353; Coverage: 100%)
Gene names: Rv1665, pks11
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 71.123Å b: 48.426Å c: 189.694Å
α: 90° β: 97.25° γ: 90°
R-values:
R R work R free
0.214 0.211 0.271
Expression system: Mycobacterium smegmatis