PDBe 4j5x

X-ray diffraction
2.8Å resolution

Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor coactivator 1; Retinoic acid receptor RXR-alpha Chains: C, D
Molecule details ›
Chains: C, D
Length: 264 amino acids
Theoretical weight: 29.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 227-462; Coverage: 51%)
  • Canonical: Q15788 (Residues: 678-691, 692-700; Coverage: 2%)
  • nullnull
Gene names: BHLHE74, NCOA1, NR2B1, RXRA, SRC1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1; Nuclear receptor subfamily 1 group I member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 38.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75469 (Residues: 130-434; Coverage: 70%)
  • Canonical: Q15788 (Residues: 678-700; Coverage: 2%)
  • nullnull
Gene names: BHLHE74, NCOA1, NR1I2, PXR, SRC1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 70.09Å b: 120.3Å c: 175.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.245 0.298
Expression system: Escherichia coli