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Modular evolution and design of the protein binding interface

X-ray diffraction
2.3Å resolution
PDB entry 4j4l coloured by chain, front view.
PDB entry 4j4l coloured by chain, side view.
PDB entry 4j4l coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GW domain-containing protein, LRRNT domain-containing protein and Interleukin-6
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Multimeric state: hetero dimer
Accessible surface area: 19737.97 Å2
Buried surface area: 1982.09 Å2
Dissociation area: 991.04 Å2
Dissociation energy (ΔGdiss): -2.17 kcal/mol
Dissociation entropy (TΔSdiss): 12.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-107391
Assembly 2
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Assembly Name: GW domain-containing protein, LRRNT domain-containing protein and Interleukin-6
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Multimeric state: hetero dimer
Accessible surface area: 19590.47 Å2
Buried surface area: 1896.37 Å2
Dissociation area: 948.19 Å2
Dissociation energy (ΔGdiss): -2.78 kcal/mol
Dissociation entropy (TΔSdiss): 12.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-107391

Macromolecules

GW domain-containing protein; LRRNT domain-containing protein
Chains: A, B
Length: 267 amino acids
Theoretical weight: 30.06 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: A4L9V2 (Residues: 43-122, 145-153; Coverage: 14%)
  • Canonical: Q4G1L3 (Residues: 54-77, 87-232; Coverage: 60%)
    • nullnull
Gene name: VLRB
Pfam:
InterPro:
CATH: Ribonuclease Inhibitor
GW domain-containing protein in PDB entry 4j4l, assembly 1, front view.
GW domain-containing protein in PDB entry 4j4l, assembly 1, side view.
GW domain-containing protein in PDB entry 4j4l, assembly 1, top view.
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Interleukin-6
Chains: C, D
Length: 168 amino acids
Theoretical weight: 19.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05231 (Residues: 47-212; Coverage: 91%)
Gene names: IFNB2, IL6
Pfam: Interleukin-6/G-CSF/MGF family
InterPro:
CATH: Growth Hormone; Chain: A;
Interleukin-6 in PDB entry 4j4l, assembly 1, front view.
Interleukin-6 in PDB entry 4j4l, assembly 1, side view.
Interleukin-6 in PDB entry 4j4l, assembly 1, top view.
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