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Tankyrase 2 in complex with 3-chloro-4-(4-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid

X-ray diffraction
1.9Å resolution
PDB entry 4j3m coloured by chain, front view.
PDB entry 4j3m coloured by chain, side view.
PDB entry 4j3m coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Poly [ADP-ribose] polymerase tankyrase-2
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Multimeric state: monomeric
Accessible surface area: 10349.63 Å2
Buried surface area: 439.89 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190549
Assembly 2 (preferred)
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Assembly Name: Poly [ADP-ribose] polymerase tankyrase-2
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Multimeric state: monomeric
Accessible surface area: 10328.72 Å2
Buried surface area: 737.33 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190549

Macromolecules

Poly [ADP-ribose] polymerase tankyrase-2
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H2K2 (Residues: 952-1161; Coverage: 18%)
Gene names: PARP5B, TANK2, TNKL, TNKS2
Pfam: Poly(ADP-ribose) polymerase catalytic domain
InterPro: Poly(ADP-ribose) polymerase, catalytic domain
CATH: Phosphoenolpyruvate Carboxykinase; domain 3
Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4j3m, assembly 2, front view.
Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4j3m, assembly 2, side view.
Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4j3m, assembly 2, top view.
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