Function and Biology

Crystals structure of Human Glucokinase in complex with small molecule activator

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: carbohydrate phosphorylation
Cellular component: nucleoplasm

EC 2.7.1.2: Glucokinase

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate.
Comments:
  • A group of enzymes found in invertebrates and microorganisms highly specific for glucose.
Systematic name:
ATP:D-glucose 6-phosphotransferase
Alternative Name(s):
  • Glucokinase (phosphorylating)
  • Glucose kinase

Sequence families

CATH Protein families (Pfam)
PF00349
Domain description: Hexokinase
Occurring in:
  1. Glucokinase
1 copy of Pfam domain PF00349 (Hexokinase) in Glucokinase in PDB 4iwv.

PF03727
Domain description: Hexokinase
Occurring in:
  1. Glucokinase
1 copy of Pfam domain PF03727 (Hexokinase) in Glucokinase in PDB 4iwv.

CATH InterPro annotations
IPR001312
Domain description: Hexokinase
Occurring in:
  1. Glucokinase
IPR022673
Domain description: Hexokinase, C-terminal
Occurring in:
  1. Glucokinase
IPR022672
Domain description: Hexokinase, N-terminal
Occurring in:
  1. Glucokinase
IPR019807
Domain description: Hexokinase, binding site
Occurring in:
  1. Glucokinase

Structure domain

CATH CATH domain
3.40.367.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Hexokinase; domain 1
Homology: Hexokinase; domain 1
Occurring in:
  1. Glucokinase
1 copy of CATH domain 3.40.367.20 (Hexokinase; domain 1) in Glucokinase in PDB 4iwv.