Structure analysis

Crystals structure of Human Glucokinase in complex with small molecule activator

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 17600 Å2
Buried surface area: 1600 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): -8 kcal/mol
Dissociation entropy (TΔSdiss): 5 kcal/mol
Interface energy (ΔGint): -4 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 456 amino acids
Theoretical weight: 50.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 15-465; Coverage: 97%)
  • Best match: P35557-3 (Residues: 12-464)
Gene name: GCK
Pfam:
InterPro:
CATH: Hexokinase; domain 1

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