PDBe 4iv1

X-ray diffraction
2.1Å resolution

Crystal structure of recombinant foot-and-mouth-disease virus A22 empty capsid

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero 240-mer (preferred)
hetero tetramer
hetero 20-mer
hetero 24-mer
hetero 60-mer
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 211 amino acids
Theoretical weight: 23.09 KDa
Source organism: Foot-and-mouth disease virus - type A
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PN23 (Residues: 726-936; Coverage: 9%)
Structure domains: Jelly Rolls
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 218 amino acids
Theoretical weight: 24.64 KDa
Source organism: Foot-and-mouth disease virus - type A
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PN23 (Residues: 287-504; Coverage: 9%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 221 amino acids
Theoretical weight: 24.25 KDa
Source organism: Foot-and-mouth disease virus - type A
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PN23 (Residues: 505-725; Coverage: 10%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 85 amino acids
Theoretical weight: 8.78 KDa
Source organism: Foot-and-mouth disease virus - type A
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PN23 (Residues: 202-286; Coverage: 4%)
Sequence domains: Viral protein VP4 subunit
Structure domains: Foot-And-Mouth Disease Virus, subunit 4

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: I222
Unit cell:
a: 327.628Å b: 341.374Å c: 363.701Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.193
Expression system: Homo sapiens