Function and Biology

Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine

Source organism: Homo sapiens
Biochemical function: transferase activity
Biological process: regulation of cellular response to heat
Cellular component: membrane

EC 2.7.11.26: [Tau protein] kinase

Reaction catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate.
Comments:
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
Systematic name:
ATP:[tau-protein] O-phosphotransferase
Alternative Name(s):
  • [Tau-protein] kinase
  • ATP:tau-protein O-phosphotransferase
  • Brain protein kinase PK40erk
  • Cdk5/p20
  • CDK5/p23
  • Glycogen synthase kinase-3-beta
  • GSK
  • Protein tau kinase
  • STK31
  • Tau kinase
  • Tau-protein kinase I
  • Tau-protein kinase II
  • Tau-tubulin kinase
  • TPK
  • TPK I
  • TPK II
  • TTK

EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein.
Comments:
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • Beta-adrenergic receptor kinase
  • Beta-IIPKC
  • Epsilon PKC
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • CK-2
  • CKI
  • CKII
  • Hpr kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • PKA
  • PKC
  • Raf kinase
  • Raf-1
  • T-antigen kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • Hydroxyalkyl-protein kinase
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • Phosphorylase B kinase kinase
  • Glycogen synthase A kinase
  • HIPK2
  • Wee 1-like kinase
  • WEE1Hu
  • Prp4 protein kinase
  • Dsk1
  • STK32
  • Wee-kinase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Glycogen synthase kinase-3 beta
1 copy of Pfam domain PF00069 (Protein kinase domain) in Glycogen synthase kinase-3 beta in PDB 4iq6.

InterPro InterPro annotations
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Glycogen synthase kinase-3 beta
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Glycogen synthase kinase-3 beta
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Glycogen synthase kinase-3 beta
IPR033573
Domain description: Glycogen synthase kinase-3 beta
Occurring in:
  1. Glycogen synthase kinase-3 beta
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Glycogen synthase kinase-3 beta

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Glycogen synthase kinase-3 beta
1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Glycogen synthase kinase-3 beta in PDB 4iq6.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Glycogen synthase kinase-3 beta
1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Glycogen synthase kinase-3 beta in PDB 4iq6.