Structure analysis

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 3,5-bis(2-(6-amino-4-methylpyridin-2-yl)ethyl)benzonitrile

X-ray diffraction
2.25Å resolution
Source organism: Bos taurus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule


Assembly 1 (preferred)
Multimeric state: homo dimer
Accessible surface area: 31900 Å2
Buried surface area: 13600 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 41 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): -130 kcal/mol
Symmetry number: 2


Chains: A, B
Length: 442 amino acids
Theoretical weight: 49.49 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P29473 (Residues: 40-482; Coverage: 37%)
Gene name: NOS3
InterPro: Nitric oxide synthase, N-terminal

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