› 4im8

X-ray diffraction
3.5Å resolution

low resolution crystal structure of mouse RAGE

Released:
DOI: 10.2210/pdb4im8/pdb
PDB entry 4im8 coloured by chain, front view.
PDB entry 4im8 coloured by chain, side view.
PDB entry 4im8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Stable RAGE-heparan sulfate complexes are essential for signal transduction.
Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD
ACS Chem Biol 8 1611-20 (2013)
PMID: 23679870

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo hexamer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178916 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Advanced glycosylation end product-specific receptor Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 22.93 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62151 (Residues: 23-230; Coverage: 55%)
Gene names: Ager, Rage
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P4132
Unit cell:
a: 115.81Å b: 115.81Å c: 115.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.258 0.336
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.
Bongarzone et al. (2017)
16 more

5 mentions without citation

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
4 more