Function and Biology

Crystal structure of a human MAIT TCR in complex with bovine MR1

Source organisms:
Biochemical function: identical protein binding
Biological process: immune system process
Cellular component: external side of plasma membrane

Sequence families

Pfam Protein families (Pfam)
PF09291
Domain description: Domain of unknown function (DUF1968)
Occurring in:
  1. TRA@ protein
1 copy of Pfam domain PF09291 (Domain of unknown function (DUF1968)) in TRA@ protein in PDB 4iiq.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
1 copy of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in Major histocompatibility complex class I-related gene protein - Beta-2-microglobulin chimera in PDB 4iiq.

InterPro InterPro annotations
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. TRA@ protein
  2. T-cell receptor beta-1 chain C region
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. TRA@ protein
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. TRA@ protein
  2. T-cell receptor beta-1 chain C region
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. TRA@ protein
  2. T-cell receptor beta-1 chain C region
  3. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
5 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Major histocompatibility complex class I-related gene protein - Beta-2-microglobulin chimera in PDB 4iiq.
4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T-cell receptor beta-1 chain C region in PDB 4iiq.
2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in TRA@ protein in PDB 4iiq.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: Murine Class I Major Histocompatibility Complex, H2-DB, subunit A, domain 1
Occurring in:
  1. Major histocompatibility complex class I-related gene protein; Beta-2-microglobulin
1 copy of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in Major histocompatibility complex class I-related gene protein - Beta-2-microglobulin chimera in PDB 4iiq.