PDBe 4ihb

X-ray diffraction
2.04Å resolution

X-RAY STRUCTURE OF THE canonical C2A DOMAIN FROM HUMAN DYSFERLIN

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dysferlin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 133 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75923 (Residues: 1-124; Coverage: 6%)
Gene names: DYSF, FER1L1
Sequence domains: C2 domain
Structure domains: C2- domain Calcium/lipid binding domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: null, SSRL BEAMLINE BL7-1
Unit cell:
a: 102.413Å b: 70.67Å c: 118.31Å
α: 90° β: 113.39° γ: 90°
R-values:
R R work R free
0.204 0.2 0.24
Expression system: Escherichia coli BL21(DE3)