PDBe 4ie2

X-ray diffraction
2.21Å resolution

Crystal structure of human Arginase-2 complexed with inhibitor 1h

Released:

Function and Biology Details

Reaction catalysed:
L-arginine + H(2)O = L-ornithine + urea. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo trimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-2, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 306 amino acids
Theoretical weight: 33.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78540 (Residues: 24-329; Coverage: 86%)
Gene name: ARG2
Sequence domains: Arginase family
Structure domains: Arginase; Chain A

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P42212
Unit cell:
a: 128.094Å b: 128.094Å c: 159.085Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.167 0.216
Expression system: Escherichia coli BL21(DE3)