PDBe 4ie1

X-ray diffraction
2Å resolution

Crystal structure of human Arginase-1 complexed with inhibitor 1h

Released:

Function and Biology Details

Reaction catalysed:
L-arginine + H(2)O = L-ornithine + urea. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 33.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05089 (Residues: 5-318; Coverage: 98%)
Gene name: ARG1
Sequence domains: Arginase family
Structure domains: Arginase; Chain A

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3
Unit cell:
a: 90.074Å b: 90.074Å c: 69.272Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.108 0.106 0.127
Expression system: Escherichia coli BL21(DE3)