PDBe 4id7

X-ray diffraction
3Å resolution

ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol

Released:

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated CDC42 kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07912 (Residues: 117-389; Coverage: 26%)
Gene names: ACK1, TNK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: I422
Unit cell:
a: 94.659Å b: 94.659Å c: 187.267Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.259
Expression system: Not provided