PDBe 4ic7

X-ray diffraction
2.6Å resolution

Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 7 Chains: A, D
Molecule details ›
Chains: A, D
Length: 442 amino acids
Theoretical weight: 49.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13164 (Residues: 1-431; Coverage: 53%)
Gene names: BMK1, ERK5, MAPK7, PRKM7
Sequence domains: Protein kinase domain
Structure domains:
Dual specificity mitogen-activated protein kinase kinase 5 Chains: B, E
Molecule details ›
Chains: B, E
Length: 126 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13163 (Residues: 16-130; Coverage: 26%)
Gene names: MAP2K5, MEK5, MKK5, PRKMK5
Sequence domains: PB1 domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P43
Unit cell:
a: 69.37Å b: 69.37Å c: 271.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.258
Expression system: Escherichia coli