Function and Biology

3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate

Source organism: Pseudomonas mevalonii
Biochemical function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological process: oxidation-reduction process
Cellular component: not assigned

EC 1.1.1.88: Hydroxymethylglutaryl-CoA reductase

Reaction catalysed:
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
Systematic name:
(R)-mevalonate:NAD(+) oxidoreductase (CoA-acylating)
Alternative Name(s):
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase
  • Beta-hydroxy-beta-methylglutaryl CoA-reductase
  • Beta-hydroxy-beta-methylglutaryl coenzyme A reductase
  • Hydroxymethylglutaryl coenzyme A reductase
  • HMG-CoA reductase
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Sequence family

CATH Protein family (Pfam)
PF00368
Domain description: Hydroxymethylglutaryl-coenzyme A reductase
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of Pfam domain PF00368 (Hydroxymethylglutaryl-coenzyme A reductase) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 4i6w.

CATH InterPro annotations
IPR023076
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR002202
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR004553
Domain description: Hydroxymethylglutaryl-CoA reductase, bacterial-type
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR009029
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR023074
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
IPR009023
Domain description: Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Structure domains

CATH CATH domains
3.90.770.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Homology: 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of CATH domain 3.90.770.10 (3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 4i6w.
3.30.70.420
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase
1 copy of CATH domain 3.30.70.420 (Alpha-Beta Plaits) in 3-hydroxy-3-methylglutaryl-coenzyme A reductase in PDB 4i6w.