Structure analysis

3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate

X-ray diffraction
1.66Å resolution
Source organism: Pseudomonas mevalonii
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 25900 Å2
Buried surface area: 11900 Å2
Dissociation area: 4,900 Å2
Dissociation energy (ΔGdiss): 81 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -123 kcal/mol
Symmetry number: 2

Macromolecules

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