Structure analysis

The Jak1 kinase domain in complex with inhibitor

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric
Accessible surface area: 14000 Å2
Buried surface area: 700 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): -5 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Interface energy (ΔGint): 2 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
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Multimeric state: monomeric
Accessible surface area: 15800 Å2
Buried surface area: 1500 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): 15 kcal/mol
Symmetry number: 1

Macromolecules

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