Structure analysis

Structure of human MHC class II protein HLA-DR1 carrying an influenza hemagglutinin peptide partially filling the binding groove

X-ray diffraction
2.12Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18400 Å2
Buried surface area: 7100 Å2
Dissociation area: 1,100 Å2
Dissociation energy (ΔGdiss): 23 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -38 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 19100 Å2
Buried surface area: 7000 Å2
Dissociation area: 1,000 Å2
Dissociation energy (ΔGdiss): 21 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -38 kcal/mol
Symmetry number: 1

Macromolecules