PDBe 4i5b

X-ray diffraction
2.12Å resolution

Structure of human MHC class II protein HLA-DR1 carrying an influenza hemagglutinin peptide partially filling the binding groove

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
truncated hemagglutinin peptide Chains: C, F
Molecule details ›
Chains: C, F
Length: 12 amino acids
Theoretical weight: 1.35 KDa
UniProt:
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 187 amino acids
Theoretical weight: 21.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01903 (Residues: 27-213; Coverage: 82%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-1 beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 192 amino acids
Theoretical weight: 22.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04229 (Residues: 31-222; Coverage: 81%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2221
Unit cell:
a: 95.811Å b: 111.381Å c: 211.544Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.237
Expression system: Spodoptera frugiperda