PDBe 4i3z

X-ray diffraction
2.05Å resolution

Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 296 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P24941 (Residues: 1-296; Coverage: 99%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-A2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 257 amino acids
Theoretical weight: 29.41 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
  • Canonical: P51943 (Residues: 165-421; Coverage: 61%)
Gene names: Ccna, Ccna2, Cyca, Cyca2
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 70.77Å b: 164.13Å c: 73.28Å
α: 90° β: 107.07° γ: 90°
R R work R free
0.199 0.197 0.228
Expression system: Escherichia coli BL21