› 4i2l

X-ray diffraction
1.43Å resolution

New HIV entry inhibitor MTSFT/T23 complex

Released:
DOI: 10.2210/pdb4i2l/pdb
PDB entry 4i2l coloured by chain, front view.
PDB entry 4i2l coloured by chain, side view.
PDB entry 4i2l coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Entry authors: Yao X, Chong HH, Waltersperger S, Wang MT, He YX, Cui S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137996 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chain: C
Molecule details ›
Chain: C
Length: 42 amino acids
Theoretical weight: 4.87 KDa
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Expression system: Not provided
UniProt:
  • Canonical: P04580 (Residues: 549-589; Coverage: 5%)
Gene name: env
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
inhibitor MTSFT Chain: D
Molecule details ›
Chain: D
Length: 38 amino acids
Theoretical weight: 4.78 KDa
Source organism: Human immunodeficiency virus type 1 (ZAIRE 6 ISOLATE)
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R32
Unit cell:
a: 43.948Å b: 43.948Å c: 238.439Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.216 0.242
Expression system: Not provided

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