PDBe 4i18

X-ray diffraction
3.24Å resolution

Crystal structure of human prolactin receptor complexed with Fab fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Prolactin receptor Chains: C, R
Molecule details ›
Chains: C, R
Length: 211 amino acids
Theoretical weight: 24.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16471 (Residues: 25-235; Coverage: 35%)
Gene name: PRLR
Structure domains: Immunoglobulins
antibody heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 236 amino acids
Theoretical weight: 25.07 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
antibody light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 217 amino acids
Theoretical weight: 23.87 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P61
Unit cell:
a: 285.826Å b: 285.826Å c: 62.248Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.191 0.246
Expression system: Escherichia coli