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Crystal structure of cIAP1 BIR3 bound to T3170284

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00653
Domain description: Inhibitor of Apoptosis domain
Occurring in:
  1. Baculoviral IAP repeat-containing protein 2
The deposited structure of PDB entry 4hy4 contains 2 copies of Pfam domain PF00653 (Inhibitor of Apoptosis domain) in Baculoviral IAP repeat-containing protein 2. Showing 1 copy in chain B.

InterPro InterPro annotation
IPR001370
Domain description: BIR repeat
Occurring in:
  1. Baculoviral IAP repeat-containing protein 2

Structure domain

CATH CATH domain
1.10.1170.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Homology: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Occurring in:
  1. Baculoviral IAP repeat-containing protein 2
The deposited structure of PDB entry 4hy4 contains 2 copies of CATH domain 1.10.1170.10 (Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A) in Baculoviral IAP repeat-containing protein 2. Showing 1 copy in chain B.

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