Assemblies
Assembly Name:
Poly [ADP-ribose] polymerase tankyrase-2
Multimeric state:
hetero dimer
Accessible surface area:
10328.11 Å2
Buried surface area:
7040.29 Å2
Dissociation area:
3,145.81
Å2
Dissociation energy (ΔGdiss):
59.32
kcal/mol
Dissociation entropy (TΔSdiss):
11.51
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-190550
Macromolecules
Chain: A
Length: 191 amino acids
Theoretical weight: 21.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Pfam: Poly(ADP-ribose) polymerase catalytic domain
InterPro:
CATH: Phosphoenolpyruvate Carboxykinase; domain 3
Length: 191 amino acids
Theoretical weight: 21.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9H2K2 (Residues: 946-1113; Coverage: 14%)
Pfam: Poly(ADP-ribose) polymerase catalytic domain
InterPro:
CATH: Phosphoenolpyruvate Carboxykinase; domain 3
![Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4hmh, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/4hmh_entity_1_front_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>4hmh</span> contains 1 copy of <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Front view.")
![Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4hmh, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/4hmh_entity_1_side_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>4hmh</span> contains 1 copy of <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Side view.")
![Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4hmh, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/4hmh_entity_1_top_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>4hmh</span> contains 1 copy of <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Top view.")
Chain: C
Length: 49 amino acids
Theoretical weight: 5.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
InterPro: Poly(ADP-ribose) polymerase, catalytic domain
CATH: YefM-like fold
Length: 49 amino acids
Theoretical weight: 5.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9H2K2 (Residues: 1114-1162; Coverage: 4%)
InterPro: Poly(ADP-ribose) polymerase, catalytic domain
CATH: YefM-like fold
![Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4hmh, assembly 1, front view.](https://www.ebi.ac.uk/pdbe/static/entry/4hmh_entity_2_front_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>4hmh</span> contains 1 copy of <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Front view.")
![Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4hmh, assembly 1, side view.](https://www.ebi.ac.uk/pdbe/static/entry/4hmh_entity_2_side_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>4hmh</span> contains 1 copy of <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Side view.")
![Poly [ADP-ribose] polymerase tankyrase-2 in PDB entry 4hmh, assembly 1, top view.](https://www.ebi.ac.uk/pdbe/static/entry/4hmh_entity_2_top_image-200x200.png "Hetero dimeric assembly 1 of PDB entry <span class='highlight'>4hmh</span> contains 1 copy of <span class='highlight'>Poly [ADP-ribose] polymerase tankyrase-2</span>. Top view.")