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Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide

Source organism: Homo sapiens
Biochemical function: antigen binding
Biological process: B cell receptor signaling pathway
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
The deposited structure of PDB entry 4hix contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin heavy constant gamma 1. Showing 1 copy in chain A [auth H].
The deposited structure of PDB entry 4hix contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Immunoglobulin kappa constant. Showing 1 copy in chain B [auth L].

PF03494
Domain description: Beta-amyloid peptide (beta-APP)
Occurring in:
  1. P3(42)
The deposited structure of PDB entry 4hix contains 1 copy of Pfam domain PF03494 (Beta-amyloid peptide (beta-APP)) in P3(42). Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR013803
Domain description: Amyloidogenic glycoprotein, amyloid-beta peptide
Occurring in:
  1. P3(42)
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
IPR037071
Domain description: Amyloidogenic glycoprotein, amyloid-beta peptide superfamily
Occurring in:
  1. P3(42)

Structure domain

CATH CATH domain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Immunoglobulin heavy constant gamma 1
  2. Immunoglobulin kappa constant
The deposited structure of PDB entry 4hix contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin heavy constant gamma 1. Showing 2 copies in chain A [auth H].
The deposited structure of PDB entry 4hix contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Immunoglobulin kappa constant. Showing 2 copies in chain B [auth L].

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