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Crystal structure of the binary Complex of KRIT1 bound to the Rap1 GTPase

X-ray diffraction
1.67Å resolution
PDB entry 4hdo coloured by chain, front view.
PDB entry 4hdo coloured by chain, side view.
PDB entry 4hdo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ras-related protein Rap-1b and Krev interaction trapped protein 1
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Multimeric state: hetero dimer
Accessible surface area: 22932.46 Å2
Buried surface area: 2875.93 Å2
Dissociation area: 792.95 Å2
Dissociation energy (ΔGdiss): -2.6 kcal/mol
Dissociation entropy (TΔSdiss): 12.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126334

Macromolecules

Krev interaction trapped protein 1
Chain: A
Length: 322 amino acids
Theoretical weight: 37.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00522 (Residues: 417-736; Coverage: 44%)
Gene names: CCM1, KRIT1
Pfam: FERM central domain
InterPro:
CATH:
Krev interaction trapped protein 1 in PDB entry 4hdo, assembly 1, front view.
Krev interaction trapped protein 1 in PDB entry 4hdo, assembly 1, side view.
Krev interaction trapped protein 1 in PDB entry 4hdo, assembly 1, top view.
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Ras-related protein Rap-1b
Chain: B
Length: 167 amino acids
Theoretical weight: 19.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61224 (Residues: 1-167; Coverage: 91%)
Gene names: OK/SW-cl.11, RAP1B
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Ras-related protein Rap-1b in PDB entry 4hdo, assembly 1, front view.
Ras-related protein Rap-1b in PDB entry 4hdo, assembly 1, side view.
Ras-related protein Rap-1b in PDB entry 4hdo, assembly 1, top view.
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