› 4hd0

X-ray diffraction
2.3Å resolution

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

Released:
DOI: 10.2210/pdb4hd0/pdb
PDB entry 4hd0 coloured by chain, front view.
PDB entry 4hd0 coloured by chain, side view.
PDB entry 4hd0 coloured by chain, top view.
Source organism: Pyrococcus furiosus DSM 3638
Primary publication:
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo O, Moiani D, Kertokalio A, Wyman C, Tainer JA, Russell P
Nucleic Acids Res 40 11435-49 (2012)
PMID: 23080121

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186413 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA double-strand break repair protein Mre11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 39.8 KDa
Source organism: Pyrococcus furiosus DSM 3638
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8U1N9 (Residues: 1-333; Coverage: 78%)
Gene names: PF1166, mre11
Sequence domains: Calcineurin-like phosphoesterase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MN 4 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 12.3.1
Spacegroup: P21
Unit cell:
a: 68.039Å b: 70.189Å c: 81.489Å
α: 90° β: 109.31° γ: 90°
R-values:
R R work R free
0.225 0.223 0.277
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Manganese Is Essential for Neuronal Health.
Horning et al. (2015)
8 more

1 mention without citation

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Limbo et al. (2012)