Function and Biology

Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor

Source organism: Homo sapiens
Biochemical function: metallopeptidase activity
Biological process: proteolysis
Cellular component: extracellular matrix

EC 3.4.24.65: Macrophage elastase

Reaction catalysed:
Hydrolysis of soluble and insoluble elastin (1). Specific cleavages are also produced at -Ala(14)-|-Leu- and -Tyr(16)-|-Leu- in the B chain of insulin (2).
Systematic name:
-
Alternative Name(s):
  • Human macrophage metalloelastase (HME)
  • Metalloelastase
  • Matrix metalloproteinase 12

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. Macrophage metalloelastase
1 copy of Pfam domain PF00413 (Matrixin) in Macrophage metalloelastase in PDB 4h76.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Macrophage metalloelastase
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Macrophage metalloelastase
IPR028718
Domain description: Macrophage metalloelastase
Occurring in:
  1. Macrophage metalloelastase
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Macrophage metalloelastase
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Macrophage metalloelastase
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Macrophage metalloelastase

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Macrophage metalloelastase
1 copy of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Macrophage metalloelastase in PDB 4h76.