Function and Biology

Crystal structure of the catalytic domain of MMP-12 in complex with a twin inhibitor.

Source organism: Homo sapiens
Biochemical function: metallopeptidase activity
Biological process: proteolysis
Cellular component: extracellular matrix

EC 3.4.24.65: Macrophage elastase

Reaction catalysed:
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
Comments:
  • Belongs to peptidase family M10B.
Systematic name:
-
Alternative Name(s):
  • Human macrophage metalloelastase (HME)
  • Metalloelastase
  • Matrix metalloproteinase 12

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. Macrophage metalloelastase
1 copy of Pfam domain PF00413 (Matrixin) in Macrophage metalloelastase in PDB 4h30.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Macrophage metalloelastase
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Macrophage metalloelastase
IPR028718
Domain description: Macrophage metalloelastase
Occurring in:
  1. Macrophage metalloelastase
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Macrophage metalloelastase
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Macrophage metalloelastase
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Macrophage metalloelastase