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Crystal structure of mutant MMP-9 catalytic domain in complex with a twin inhibitor.

X-ray diffraction
1.59Å resolution
PDB entry 4h1q coloured by chain, front view.
PDB entry 4h1q coloured by chain, side view.
PDB entry 4h1q coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: monomeric
Accessible surface area: 8517.12 Å2
Buried surface area: 265.68 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147085
Assembly 2 (preferred)
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Assembly Name: 67 kDa matrix metalloproteinase-9
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Multimeric state: monomeric
Accessible surface area: 8132.03 Å2
Buried surface area: 178.38 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147085

Macromolecules

67 kDa matrix metalloproteinase-9
Chains: A, B
Length: 160 amino acids
Theoretical weight: 17.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14780 (Residues: 110-444; Coverage: 23%)
Gene names: CLG4B, MMP9
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
67 kDa matrix metalloproteinase-9 in PDB entry 4h1q, assembly 2, front view.
67 kDa matrix metalloproteinase-9 in PDB entry 4h1q, assembly 2, side view.
67 kDa matrix metalloproteinase-9 in PDB entry 4h1q, assembly 2, top view.
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