› › Structure analysis

Crystal structure of LSD2-NPAC with H3 in space group P21

X-ray diffraction
2.506Å resolution
PDB entry 4gur coloured by chain, front view.
PDB entry 4gur coloured by chain, side view.
PDB entry 4gur coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero trimer
Accessible surface area: 31518.05 Å2
Buried surface area: 6250.01 Å2
Dissociation area: 1,023.81 Å2
Dissociation energy (ΔGdiss): 9.07 kcal/mol
Dissociation entropy (TΔSdiss): 7.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160859

Macromolecules

Lysine-specific histone demethylase 2
Chain: A
Length: 776 amino acids
Theoretical weight: 87.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NB78 (Residues: 51-822; Coverage: 94%)
Gene names: AOF1, C6orf193, KDM1B, LSD2
Pfam:
InterPro:
Lysine-specific histone demethylase 2 in PDB entry 4gur, assembly 1, front view.
Lysine-specific histone demethylase 2 in PDB entry 4gur, assembly 1, side view.
Lysine-specific histone demethylase 2 in PDB entry 4gur, assembly 1, top view.
Molecule details ›

Search similar proteins

Cytokine-like nuclear factor N-PAC
Chain: B
Length: 124 amino acids
Theoretical weight: 13.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q49A26 (Residues: 152-268; Coverage: 21%)
Gene names: GLYR1, HIBDL, NDF, NP60, NPAC
Cytokine-like nuclear factor N-PAC in PDB entry 4gur, assembly 1, front view.
Cytokine-like nuclear factor N-PAC in PDB entry 4gur, assembly 1, side view.
Cytokine-like nuclear factor N-PAC in PDB entry 4gur, assembly 1, top view.
Molecule details ›

Search similar proteins

Histone H3.3
Chain: C
Length: 21 amino acids
Theoretical weight: 2.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P84243 (Residues: 2-22; Coverage: 15%)
Gene names: H3-3A, H3-3B, H3.3A, H3.3B, H3F3, H3F3A, H3F3B, PP781
InterPro: Histone H3/CENP-A
Histone H3.3 in PDB entry 4gur, assembly 1, front view.
Histone H3.3 in PDB entry 4gur, assembly 1, side view.
Histone H3.3 in PDB entry 4gur, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links