PDBe 4gt7

X-ray diffraction
2.61Å resolution

An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, non-receptor binding conformation

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin heavy constant epsilon Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 221 amino acids
Theoretical weight: 24.72 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01854 (Residues: 210-426; Coverage: 51%)
Gene name: IGHE
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P21
Unit cell:
a: 106.753Å b: 104.807Å c: 45.899Å
α: 90° β: 94.51° γ: 90°
R-values:
R R work R free
0.192 0.19 0.253
Expression system: Trichoplusia ni