› 4gmv

X-ray diffraction
2.4Å resolution

Crystal Structure of the coiled-coil, RA and PH domains of Lamellipodin

Released:
DOI: 10.2210/pdb4gmv/pdb
PDB entry 4gmv coloured by chain, front view.
PDB entry 4gmv coloured by chain, side view.
PDB entry 4gmv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Chang YC, Zhang H, Brennan ML, Wu J
Protein Cell 4 211-9 (2013)
PMID: 23483482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-associated and pleckstrin homology domains-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 281 amino acids
Theoretical weight: 33.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q70E73 (Residues: 240-520; Coverage: 23%)
Gene names: ALS2CR18, ALS2CR9, KIAA1681, LPD, PREL2, RAPH1, RMO1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2
Unit cell:
a: 117.617Å b: 96.972Å c: 76.824Å
α: 90° β: 126.99° γ: 90°
R-values:
R R work R free
0.242 0.24 0.283
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling.
Li et al. (2015)
12 other articles

5 mentions without citation

The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.
Zhang et al. (2014)
4 more