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A2-MHC Complex carrying FATGIGIITV

X-ray diffraction
2.753Å resolution
PDB entry 4gkn coloured by chain, front view.
PDB entry 4gkn coloured by chain, side view.
PDB entry 4gkn coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19268.96 Å2
Buried surface area: 5001.5 Å2
Dissociation area: 872.81 Å2
Dissociation energy (ΔGdiss): 10.37 kcal/mol
Dissociation entropy (TΔSdiss): 7.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137761
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 19231.34 Å2
Buried surface area: 5162.13 Å2
Dissociation area: 889.99 Å2
Dissociation energy (ΔGdiss): 9.98 kcal/mol
Dissociation entropy (TΔSdiss): 7.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137761

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 4gkn, assembly 1, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 4gkn, assembly 1, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 4gkn, assembly 1, top view.
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 4gkn, assembly 1, front view.
Beta-2-microglobulin in PDB entry 4gkn, assembly 1, side view.
Beta-2-microglobulin in PDB entry 4gkn, assembly 1, top view.
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FAT Cognate peptide
Chains: C, F
Length: 10 amino acids
Theoretical weight: 991 Da
Source organism: synthetic construct
Expression system: Not provided
FAT Cognate peptide in PDB entry 4gkn, assembly 1, front view.
FAT Cognate peptide in PDB entry 4gkn, assembly 1, side view.
FAT Cognate peptide in PDB entry 4gkn, assembly 1, top view.
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