PDBe 4g8o

X-ray diffraction
2.71Å resolution

Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 376 amino acids
Theoretical weight: 42.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05121 (Residues: 28-402; Coverage: 99%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P1
Unit cell:
a: 65.335Å b: 75.317Å c: 105.002Å
α: 91.32° β: 93.49° γ: 115.65°
R-values:
R R work R free
0.241 0.239 0.268
Expression system: Escherichia coli BL21(DE3)