PDBe 4g8a

X-ray diffraction
2.4Å resolution

Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Toll-like receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 635 amino acids
Theoretical weight: 72.29 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O00206 (Residues: 23-629; Coverage: 74%)
  • Best match: O00206-2 (Residues: 1-589)
Gene name: TLR4
Sequence domains:
Structure domains: Ribonuclease Inhibitor
Lymphocyte antigen 96 Chains: C, D
Molecule details ›
Chains: C, D
Length: 144 amino acids
Theoretical weight: 16.59 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q9Y6Y9 (Residues: 17-160; Coverage: 100%)
Gene names: ESOP1, LY96, MD2
Structure domains: Immunoglobulin-like

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2
Unit cell:
a: 158.038Å b: 124.68Å c: 109.14Å
α: 90° β: 115.72° γ: 90°
R-values:
R R work R free
0.202 0.199 0.249
Expression system: Drosophila