Function and Biology

Crystal structure of TNF-alpha in complex with Infliximab Fab fragment

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor binding
Biological process: immune response
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family) in Tumor necrosis factor, soluble form in PDB 4g3y.

InterPro InterPro annotations
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. infliximab Fab H
  2. infliximab Fab L
2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in infliximab Fab H in PDB 4g3y.
4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in infliximab Fab L in PDB 4g3y.
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form in PDB 4g3y.