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Structure of M2 pyruvate kinase in complex with phenylalanine

X-ray diffraction
2.55Å resolution
PDB entry 4fxf coloured by chain, front view.
PDB entry 4fxf coloured by chain, side view.
PDB entry 4fxf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pyruvate kinase PKM
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Multimeric state: homo tetramer
Accessible surface area: 72132.82 Å2
Buried surface area: 21972.5 Å2
Dissociation area: 2,429.94 Å2
Dissociation energy (ΔGdiss): 24.42 kcal/mol
Dissociation entropy (TΔSdiss): 16.1 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-146985

Macromolecules

Pyruvate kinase PKM
Chains: A, B, C, D
Length: 551 amino acids
Theoretical weight: 60.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Pfam:
InterPro:
CATH:
Pyruvate kinase PKM in PDB entry 4fxf, assembly 1, front view.
Pyruvate kinase PKM in PDB entry 4fxf, assembly 1, side view.
Pyruvate kinase PKM in PDB entry 4fxf, assembly 1, top view.
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