Function and Biology

Carbonic Anhydrase II in complex with N'-sulfamoylpyrrolidine-1-carboximidamide

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: morphogenesis of an epithelium
Cellular component: membrane

EC 4.2.1.1: Carbonic anhydrase

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O.
Comments:
  • The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH.
  • It is widespread and found in archaea, bacteria, and eukaryotes.
  • Three distinct classes exist, and appear to have evolved independently.
Systematic name:
Carbonic acid hydro-lyase (carbon-dioxide-forming)
Alternative Name(s):
  • Anhydrase
  • Carbonate anhydrase
  • Carbonic acid anhydrase
  • Carbonate dehydratase
  • Carbonic anhydrase A
  • Carboxyanhydrase
  • Carbonic dehydratase
  • Carbonate hydro-lyase

Sequence family

Pfam Protein family (Pfam)
PF00194
Domain description: Eukaryotic-type carbonic anhydrase
Occurring in:
  1. Carbonic anhydrase 2
1 copy of Pfam domain PF00194 (Eukaryotic-type carbonic anhydrase) in Carbonic anhydrase 2 in PDB 4frc.

InterPro InterPro annotations
IPR001148
Domain description: Alpha carbonic anhydrase
Occurring in:
  1. Carbonic anhydrase 2
IPR036398
Domain description: Alpha carbonic anhydrase superfamily
Occurring in:
  1. Carbonic anhydrase 2
IPR018338
Domain description: Carbonic anhydrase, alpha-class, conserved site
Occurring in:
  1. Carbonic anhydrase 2
IPR023561
Domain description: Carbonic anhydrase, alpha-class
Occurring in:
  1. Carbonic anhydrase 2

Structure domain

CATH CATH domain
3.10.200.10
Class: Alpha Beta
Architecture: Roll
Topology: Carbonic Anhydrase II
Homology: Carbonic Anhydrase II
Occurring in:
  1. Carbonic anhydrase 2
1 copy of CATH domain 3.10.200.10 (Carbonic Anhydrase II) in Carbonic anhydrase 2 in PDB 4frc.