Function and Biology

Crystal structure of HLA-DM bound to HLA-DR1

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: antigen processing and presentation
Cellular component: MHC class II protein complex

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
InterPro InterPro annotations
IPR000353
IPR001003
Domain description: MHC class II, alpha chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DM alpha chain

Structure domains

CATH CATH domains
3.10.320.10
Class: Alpha Beta
Architecture: Roll
Topology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Homology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
  3. HLA class II histocompatibility antigen, DM alpha chain
  4. HLA class II histocompatibility antigen, DM beta chain
4 copies of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DM beta chain in PDB 4fqx.
3 copies of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DM alpha chain in PDB 4fqx.
2 copies of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 4fqx.
1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DR alpha chain in PDB 4fqx.