Structure analysis

Crystal structure of HLA-DM bound to HLA-DR1

X-ray diffraction
2.599Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero pentamer (preferred)
hetero dimer
hetero trimer
Entry contents: 5 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 34700 Å2
Buried surface area: 15000 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -69 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 18900 Å2
Buried surface area: 5400 Å2
Dissociation area: 2,700 Å2
Dissociation energy (ΔGdiss): 39 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -32 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero trimer
Accessible surface area: 18900 Å2
Buried surface area: 6500 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -27 kcal/mol
Symmetry number: 1

Macromolecules