› › Function and Biology

Human MetAP1 with bengamide analog Y16, in Mn form

Source organism: Homo sapiens
Biochemical function: metalloaminopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

Quick links

EC 3.4.11.18: Methionyl aminopeptidase

Reaction catalysed:
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Systematic name:
-
Alternative Name(s):
  • L-methionine aminopeptidase
  • MAP
  • Methionine aminopeptidase
  • Peptidase M

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00557
Domain description: Metallopeptidase family M24
Occurring in:
  1. Methionine aminopeptidase 1
The deposited structure of PDB entry 4fli contains 1 copy of Pfam domain PF00557 (Metallopeptidase family M24) in Methionine aminopeptidase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001714
Domain description: Peptidase M24, methionine aminopeptidase
Occurring in:
  1. Methionine aminopeptidase 1
IPR002467
Domain description: Peptidase M24A, methionine aminopeptidase, subfamily 1
Occurring in:
  1. Methionine aminopeptidase 1
IPR036005
Domain description: Creatinase/aminopeptidase-like
Occurring in:
  1. Methionine aminopeptidase 1
IPR000994
Domain description: Peptidase M24
Occurring in:
  1. Methionine aminopeptidase 1

Structure domain

CATH CATH domain
3.90.230.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Creatine Amidinohydrolase
Homology: Creatinase/methionine aminopeptidase superfamily
Occurring in:
  1. Methionine aminopeptidase 1
The deposited structure of PDB entry 4fli contains 1 copy of CATH domain 3.90.230.10 (Creatine Amidinohydrolase) in Methionine aminopeptidase 1. Showing 1 copy in chain A.

Quick links