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Structural and Biophysical Characterization of the Syk Activation Switch

X-ray diffraction
1.79Å resolution
PDB entry 4fl1 coloured by chain, front view.
PDB entry 4fl1 coloured by chain, side view.
PDB entry 4fl1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase SYK
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Multimeric state: monomeric
Accessible surface area: 13354.24 Å2
Buried surface area: 867.51 Å2
Dissociation area: 388.25 Å2
Dissociation energy (ΔGdiss): 1.76 kcal/mol
Dissociation entropy (TΔSdiss): 5.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155056

Macromolecules

Tyrosine-protein kinase SYK
Chain: A
Length: 291 amino acids
Theoretical weight: 33.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 356-635; Coverage: 44%)
Gene name: SYK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase SYK in PDB entry 4fl1, assembly 1, front view.
Tyrosine-protein kinase SYK in PDB entry 4fl1, assembly 1, side view.
Tyrosine-protein kinase SYK in PDB entry 4fl1, assembly 1, top view.
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