› 4f8a

X-ray diffraction
2.2Å resolution

Cyclic nucleotide binding-homology domain from mouse EAG1 potassium channel

Released:
DOI: 10.2210/pdb4f8a/pdb
PDB entry 4f8a coloured by chain, front view.
PDB entry 4f8a coloured by chain, side view.
PDB entry 4f8a coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel.
Marques-Carvalho MJ, Sahoo N, Muskett FW, Vieira-Pires RS, Gabant G, Cadene M, Schönherr R, Morais-Cabral JH
J Mol Biol 423 34-46 (2012)
PMID: 22732247

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily H member 1 Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.02 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q60603 (Residues: 552-707; Coverage: 16%)
Gene names: Eag, Kcnh1
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 60.346Å b: 60.346Å c: 85.415Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Structural insights into the mechanisms of CNBD channel function.
James et al. (2018)
5 more

4 mentions without citation

The structural mechanism of KCNH-channel regulation by the eag domain.
Haitin et al. (2013)
3 more