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Crystal structure of human CDK8/CYCC in complex with compound 1 (N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamide)

Source organism: Homo sapiens
Biochemical function: identical protein binding
Biological process: positive regulation of transcription by RNA polymerase II
Cellular component: CKM complex

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EC 2.7.11.23: [RNA-polymerase]-subunit kinase

Reaction catalysed:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Systematic name:
ATP:[DNA-directed RNA polymerase] phosphotransferase
Alternative Name(s):
  • CTD kinase
  • STK9

EC 2.7.11.22: Cyclin-dependent kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
  • Bur1
  • Bur1 Cdk
  • CDK
  • Cak1
  • Cak1p
  • Cdc2
  • Cdc2 kinase
  • Cdc28p
  • Cdk-activating kinase
  • Cdk-activating protein kinase
  • Cdk1
  • Cdk2
  • Cdk2
  • Cdk3
  • Cdk4
  • Cdk5
  • Cdk6
  • Cdk7
  • Cdk8
  • Cdk9
  • Cyclin A-activated cdc2
  • Cyclin A-activated cdk2
  • Cyclin D-cdk6 kinase
  • Cyclin D-dependent kinase
  • Cyclin E kinase
  • Cyclin-A associated kinase
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase-2
  • Cyclin-dependent kinase-4
  • Cyclin-dependent protein kinase activating kinase
  • Cyk
  • D-type cyclin kinase
  • Nclk
  • Neuronal cdc2-like kinase
  • PCTAIRE-1
  • STK25

GO terms

Sequence families

Pfam Protein families (Pfam)
PF16899
Domain description: Cyclin C-terminal domain
Occurring in:
  1. Cyclin-C

PF00134
Domain description: Cyclin, N-terminal domain
Occurring in:
  1. Cyclin-C
The deposited structure of PDB entry 4f6w contains 1 copy of Pfam domain PF00134 (Cyclin, N-terminal domain) in Cyclin-C. Showing 1 copy in chain B.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 8
The deposited structure of PDB entry 4f6w contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Cyclin-dependent kinase 8. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013763
Domain description: Cyclin-like domain
Occurring in:
  1. Cyclin-C
IPR036915
Domain description: Cyclin-like superfamily
Occurring in:
  1. Cyclin-C
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent kinase 8
IPR006671
Domain description: Cyclin, N-terminal
Occurring in:
  1. Cyclin-C
IPR043198
Domain description: Cyclin/Cyclin-like subunit Ssn8
Occurring in:
  1. Cyclin-C
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Cyclin-dependent kinase 8
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Cyclin-dependent kinase 8
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Cyclin-dependent kinase 8

Structure domains

CATH CATH domains
1.10.472.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cyclin A; domain 1
Homology: Cyclin-like
Occurring in:
  1. Cyclin-C
The deposited structure of PDB entry 4f6w contains 2 copies of CATH domain 1.10.472.10 (Cyclin A; domain 1) in Cyclin-C. Showing 2 copies in chain B.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Cyclin-dependent kinase 8
The deposited structure of PDB entry 4f6w contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Cyclin-dependent kinase 8. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Cyclin-dependent kinase 8
The deposited structure of PDB entry 4f6w contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Cyclin-dependent kinase 8. Showing 1 copy in chain A.

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