PDBe 4f0x

X-ray diffraction
3.29Å resolution

Crystal structure of human Malonyl-CoA Decarboxylase (Peroxisomal Isoform)

Released:

Function and Biology Details

Reaction catalysed:
Malonyl-CoA = acetyl-CoA + CO(2). 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malonyl-CoA decarboxylase, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 458 amino acids
Theoretical weight: 51.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95822 (Residues: 39-493; Coverage: 92%)
Gene name: MLYCD
Sequence domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 80.42Å b: 103.31Å c: 134.24Å
α: 95.32° β: 90.22° γ: 94.46°
R-values:
R R work R free
0.246 0.244 0.267
Expression system: Escherichia coli BL21(DE3)