Function and Biology

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone

Source organism: Rattus norvegicus
Biochemical function: transferase activity
Biological process: long-chain fatty acid transport
Cellular component: mitochondrial inner membrane

EC 2.3.1.21: Carnitine O-palmitoyltransferase

Reaction catalysed:
Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
Comments:
  • Broad specificity to acyl group, over the range C(8) to C(18); optimal activity with palmitoyl-CoA (cf. EC 2.3.1.7 and EC 2.3.1.137).
Systematic name:
Palmitoyl-CoA:L-carnitine O-palmitoyltransferase
Alternative Name(s):
  • L-carnitine palmitoyltransferase
  • CPT
  • CPT I (outer membrane carnitine palmitoyl transferase)
  • CPT-A
  • CPT-B
  • CPTi
  • CPTo
  • Acylcarnitine transferase
  • Carnitine palmitoyltransferase
  • Carnitine palmitoyltransferase I
  • Carnitine palmitoyltransferase II
  • Carnitine palmitoyltransferase-A
  • Outer malonyl-CoA inhibitable carnitine palmitoyltransferase
  • Palmitoylcarnitine transferase

Sequence family

Pfam Protein family (Pfam)
PF00755
Domain description: Choline/Carnitine o-acyltransferase
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial
1 copy of Pfam domain PF00755 (Choline/Carnitine o-acyltransferase) in Carnitine O-palmitoyltransferase 2, mitochondrial in PDB 4eyw.

InterPro InterPro annotation
IPR000542
Domain description: Acyltransferase ChoActase/COT/CPT
Occurring in:
  1. Carnitine O-palmitoyltransferase 2, mitochondrial