Structure analysis

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone

X-ray diffraction
1.885Å resolution
Source organism: Rattus norvegicus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 26400 Å2
Buried surface area: 1600 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Interface energy (ΔGint): -2 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 634 amino acids
Theoretical weight: 71.53 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18886 (Residues: 27-658; Coverage: 96%)
Gene names: Cpt-2, Cpt2
Pfam: Choline/Carnitine o-acyltransferase
InterPro: Acyltransferase ChoActase/COT/CPT

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